mab 274  (R&D Systems)

Journal: International Journal of Molecular Sciences

Article Title: Distinct Signaling Cascades Elicited by Different Formyl Peptide Receptor 2 (FPR2) Agonists

doi: 10.3390/ijms14047193

Figure Lengend Snippet: Intracellular signaling cascades triggered by peptides associated with inflammatory and anti-inflammatory responses.

Article Snippet: Pretreatment of monocytes with the FPR2 agonist, D2D3 88–274 , markedly decreases chemokine-induced integrin-dependent rapid cell adhesion [ ], indicating that FPR2 regulates leukocyte chemotaxis as a direct mediator of cell migration and/or by suppressing cell responses to chemokines by desensitizing chemokine receptors [ ]. uPAR works in concert with co-receptors, including integrins, FPR2 and epidermal growth factor receptor (EGFR), which may be dynamically organized into a multiprotein signaling receptor complex to initiate cell signaling [ ].

Techniques: Chemotaxis Assay, Expressing, Inhibition, Activity Assay, Phospho-proteomics, Translocation Assay, Activation Assay, Migration